Digital Health in USA: Challenges, Opportunities, and What’s Next

Digital health in the USA has surged like never before, transforming from niche pilots into a core engine of the healthcare system. Enterprise budgets are moving away from legacy tech stacks toward agile digital health platforms that cut administrative drag, unlock patient data insights, and deliver measurable ROI across the US healthcare market.

This shift is reshaping how buyers make decisions. In H1 2025, U.S. healthtech attracted $6.4B across 245 deals (Rock Health), showing how much confidence investors and health systems now place in digital platforms that can scale and deliver real business impact. Buyers aren’t looking for experimental pilots anymore; they want proof of value, fast.

To succeed, companies must navigate a set of critical fronts to truly capitalize on this evolution. As digital health continues to advance, so do the challenges and the opportunities that will define its future. This article explores these fronts, from value-based care and interoperability to EHR integration, regulatory compliance, and patient engagement, helping you spot where the real opportunities lie and turn this digital transformation into sustainable growth.

Seizing Growth Opportunities in the US Digital Health Market

Winning in the US digital health market now depends on more than innovation; it requires proving operational ROI and revenue impact upfront. As health systems modernize, enterprise buyers are raising the bar: they want platforms that reduce administrative workload, accelerate clinical workflows, enhance Electronic Health Record (EHR) interoperability, and turn health informatics into actionable business insights. Vendors that can demonstrate integration readiness and measurable ROI early are the ones breaking through procurement barriers.

A powerful example is Epic Systems’ partnership with Microsoft to embed AI-driven documentation tools directly into EHR workflows. This move showed buyers that digital platforms can cut charting time by 50%, directly boosting clinician productivity and revenue. To compete, vendors must present integration proof (EHR, claims, analytics) and tie pilots to revenue-linked moments like risk-based contracts or service-line expansions.

When your pitch connects medical data directly to financial metrics, you move the conversation from features to outcomes, and that’s exactly what enterprise buyers are ready to invest in.

Breaking Through Regulatory & Data Barriers to Drive Adoption

As digital healthcare adoption accelerates, the regulatory landscape in the USA has grown more complex shifting from loose guidelines to enforceable standards that directly impact purchasing decisions. Scaling digital healthcare in the USA now hinges on regulatory compliance and secure data exchange.

The HTI-1 Final Rule requires transparency for AI-enabled clinical decision support and strengthens data-sharing mandates, meaning compliance must be built into your product from day one. At the same time, TEFCA is driving nationwide interoperability, and major vendors are onboarding as Qualified Health Information Networks (QHINs), making cross-network data exchange the new baseline.

To win enterprise deals, make it easy for buyers to say yes. Build Health Insurance Portability and Accountability Act (HIPAA)-compliant, Fast Healthcare Interoperability Resources (FHIR)-based Application Programming Interfaces (APIs), provide audit-ready documentation, and publish security playbooks upfront. Collaborate early with buyers’ legal and IT teams to shorten security reviews and remove deployment risk.

Your competitive edge is showing how compliant data exchange accelerates care delivery and revenue capture. When you reduce friction in procurement, you transition from a vendor to a strategic partner, often before the RFP is even issued.

Accelerating Telehealth & Virtual Care Deployment

Once seen as a temporary fix during the pandemic, telehealth has rapidly matured into a core delivery model for modern healthcare. Its ability to expand access, cut costs, and reduce care delays has made it indispensable for health systems and payers alike. Among Medicare beneficiaries, usage in Q4-2023 held steady at 12%, nearly double pre-pandemic levels.

According to a study by  Markets & Data, the global telehealth and telemedicine market is projected to grow from USD 109.61 billion in 2023 to USD 346.44 billion by 2031, at a CAGR of 15.47%, underscoring just how quickly the category is scaling.

To win enterprise deals in this expanding space, vendors must present telemedicine as an end-to-end operating system: modular health apps, embedded scheduling, device integration, and analytics that clearly prove ROI.

Teladoc Health has pioneered this approach, offering integrated behavioral health, chronic care, and primary care under one platform, which has secured them multi-year contracts with US health systems. Their success stems from focusing on business metrics: lowering no-show rates, boosting visit volumes, and reducing ER utilization.

To compete, vendors must match this operational mindset with 30–60-day rollouts, embedded EHR integration (orders, notes, billing), and reimbursement playbooks, plus dashboards that link virtual encounters directly to cash flow. Framing telehealth as a revenue engine, not just a feature, is what accelerates enterprise approvals and drives large-scale adoption in the US healthtech market.

Proving ROI & Capturing Value from Digital Health Investments

In a margin-pressured market, proving ROI has become the make-or-break factor for digital health adoption. Procurement leaders are now KPI-first, and every deal hinges on clear evidence of financial impact. To win, vendors must embed ROI proof into every pitch and show how their platform drives:

• Operational savings (less admin time, faster claims cycles)

• Revenue lift (incremental visits, care-at-home programs)

• Retention gains (stronger panel adherence, CLV growth)

Tie these metrics to dashboards built on your health record layer and commit to quarterly value reviews to keep finance teams engaged. Market signals are on your side, data shows larger deal sizes and rising investor confidence in durable, unit-economic models. Pair this with outcomes-based pricing or shared-savings contracts to de-risk adoption and speed up signatures.

Close the loop by publishing change logs and compliance attestations to give legal teams confidence. When you quantify impact and align incentives, renewals become frictionless, and expansions follow naturally.

Positioning for What’s Next in Digital Health (USA)

The next wave of digital health in the USA is being driven by two forces redefining enterprise strategies: national interoperability and pragmatic AI. TEFCA’s 2025 roadmap, combined with rapid onboarding of Qualified Health Information Networks (QHINs), is turning cross-network patient data exchange into a baseline requirement. At the same time, the American Medical Association reports that two-thirds of physicians now use medical AI, with adoption rising year over year.

Mayo Clinic is already leading the way into the healthcare future. As noted by the American Hospital Association, Mayo has partnered with NVIDIA to launch an AI computing platform powered by DGX SuperPOD systems. It supports new models for digital pathology, drug discovery, and precision medicine, and is part of Mayo’s “Bold. Forward. Unbound.” strategy.

This platform powers its AI Factory, which uses FHIR-based pipelines to organize clinical data and run predictive models in real time. This shift isn’t about showing off technology; it’s about driving real ROI, predicting bed needs, cutting documentation time, and improving care pathways to protect margins.

To compete at this level, vendors must move beyond showcasing features and start proving operational value. Build explainable AI to meet HTI-1 requirements, embed medical data layers that unify information across care settings, and position platforms as operational engines rather than just clinical tools.

Investors and health systems are actively funding solutions that blend interoperability, compliance, and profitability, and vendors who align their digital transformation of healthcare in the USA strategy with these pillars can shorten deal cycles, reduce adoption risk, and win larger enterprise contracts.

Accelerate Your Digital Health Growth Strategy

The digital health market in the USA is no longer exploratory; it’s execution driven. Budgets are shifting fast, regulations are tightening, and enterprise buyers expect platforms that prove ROI from day one. Whether it’s overcoming regulatory challenges, deploying telehealth and virtual care at scale, or proving measurable returns on healthtech investments, one thing is clear: the winners will be those who align innovation with business outcomes.

That’s where partnering with the right experts matters. At Xcel Global Panel, we help digital health vendors position their solutions for enterprise-scale growth, from customer journey mapping and healthcare IT integration strategies to building ROI models and GTM playbooks that resonate with C-suite buyers.

If you’re ready to move beyond early-stage experiments and turn your healthcare vision into a market-leading business, now is the time. Contact us to build your growth roadmap and capture the next buying cycle together.